|
KMID : 0603820170230030261
|
|
Journal of Experimental & Biomedical Science
2017 Volume.23 No. 3 p.261 ~ p.267
|
|
|
Korean Red Ginseng (Panax ginseng) Potentiates the Inhibitory Actions of Testosterone on Obesity and Adipogenesis in High Fat Diet-Fed Castrated Mice
|
|
Park Dong-Min
Yoon Mi-Chung
|
|
|
Abstract
|
|
|
It has been suggested that ginseng is beneficial for ameliorating the aging males' symptoms, such as weight gain, fatigue,
erectile dysfunction, and depression, in elderly men with testosterone deficiency. We thus investigated the effects of
Korean red ginseng (Panax ginseng C.A. Meyer; Araliaceae) on obesity in a mouse model of testosterone deficiency
(castrated C57BL/6J mice). The effects of ginseng extract (GE) and/or testosterone on obesity and adipogenesis in high-fat diet (HFD)-fed castrated C57BL/6J mice and 3T3-L1 adipocytes were examined using in vivo and in vitro approaches.
After feeding mice a HFD for 8 weeks, we found that mice also receiving GE and/or testosterone showed decreased
body weight, adipose tissue mass, adipocyte size, and hepatic lipid accumulation compared with untreated HFD-fed
mice. Expression of adipogenic genes (PPARγ, C/EBPα, and aP2) was decreased by GE and/or testosterone in adipose
tissues. Consistent with the in vivo data, lipid accumulation and the mRNA expression of adipogenesis genes in 3T3-L1
adipocytes were decreased by GE, ginsenosides, and testosterone. The inhibitory effects of GE (or ginsenosides) were
comparable to those of testosterone, and the effects of co-treatment with GE (or ginsenosides) and testosterone were
greater than those of testosterone alone in vivo and in vitro. Our results indicate that ginseng may be able to potentiate
the inhibitory effects of testosterone on obesity and adipogenesis in HFD-fed castrated mice, providing possible therapeutic
implications in men with testosterone deficiency.
|
|
|
KEYWORD
|
|
|
3T3-L1 cell , Adipogenic gene , Ginsenosides , Lipid accumulation , Testosterone deficiency
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|